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Veterinary
Gastrointestinal
Nutrition

Esomeprazole in the treatment of equine glandular gastric disease

02 September 2021
Clinical
7 mins read
02 September 2021
Volume 5 · Issue 5
Figure 3. Case 5. 6-year-old, Welsh Pony, mare. Before (a) and after (b) treatment with esomeprazole for 14 days.
Figure 3. Case 5. 6-year-old, Welsh Pony, mare. Before (a) and after (b) treatment with esomeprazole for 14 days.

Abstract

Background:

Equine glandular gastric disease is a highly prevalent disease, for which there is no universally effective treatment. Given the widespread use of esomeprazole in the treatment of peptic ulcer disease in humans, its use in horses warrants further investigation.

Objective:

To assess rates of healing of equine glandular gastric disease using oral esomeprazole.

Study design:

Retrospective case series.

Methods:

Medical records and gastroscopy images of horses diagnosed with equine glandular gastric disease and treated with esomeprazole by Avon Ridge Equine Veterinary Services were reviewed.

Results:

Out of four horses treated with esomeprazole for 28 days, 75% (three) healed and 25% (one) did not improve. Out of three horses treated with esomeprazole for 14 days, 67% (two) healed and 33% (one) did not improve.

Main limitations:

The study was limited by its retrospective nature and small sample size.

Conclusions:

Esomeprazole may be a valid first-line treatment option for equine glandular gastric disease. Larger and more robust studies of esomeprazole are warranted.

Equine glandular gastric disease (EGGD) is a highly prevalent condition in performance horses (Hepburn and Proudman 2014; Sykes et al, 2015a). Studies have detailed the prevalence of EGGD across a variety of equestrian disciplines and horse populations:, reporting a prevalence of 47–65% in thoroughbred racehorses (Begg and O'Sullivan 2003; Sykes et al, 2015); 16–35% in endurance horses (Nieto et al, 2004; Tamzali et al, 2011) and 54–57% in leisure horses (Husted et al, 2009; Luthersson et al, 2009; Malmkvist et al, 2012). While acid injury is not thought to initiate EGGD, acid suppression appears to be an important factor in healing these lesions (Sykes et al, 2015a).

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equine glandular gastric disease
esomeprazole
gastric ulcer
proton pump inhibitor